Paulson-Khand reaction

Although this has been mentioned and presented during one of our group meetings by a third-year graduate student who specializes in studying Paulson-Khand, I never bothered to further investigate the reaction until now.… Continue reading


  By stringent definition, organometallics encompasses the study of organic compounds that contain a carbon-metal bond. It remarkably combines organic and inorganic chemistry into one beautiful mesh where really cool chemistry can occur.… Continue reading

Wittig reaction…

basically illustrates the transformation of an aldehyde or ketone to an alkene. You start with building the triphenylphosphonium ylide (Wittig reagent). This can simply be done through the reaction of an alkyl halide… Continue reading


Originally posted on Org Prep Daily:
Beautiful asymmetric transition metal-catalysed chemistry with phosphine ligands chiral on phosphorus dates back to Knowles and Mislow. But these P-stereogenic homochiral phosphines are usualy harder to make, so they were eventually supplanted by ligands with chirality…

Mannich reaction!

It’s a pretty cool reaction where you end up making Mannich bases, which are beta-amino-carbonyl compounds. The reaction involves acetaldehyde, primary or secondary amines (or ammonia), and a carbonyl compound with an acidic… Continue reading

Sheri Sangji’s death from handling t-butyllithium improperly

Remember this story? Well, a verdict has finally been reached (about a week or so ago) on the sentencing of Professor Harran (the PI who Sheri Sangji was working under) and his role… Continue reading

Yamaguchi esterification

I love the name of this one, it reminds me of the Tamagotchi toys I used to play with as a kid (reference for anyone’s personal interest in the game: It’s basically the… Continue reading

Birch reduction

Discovered in the mid-20th century by an Australian chemist, the Birch reduction demonstrates a beautiful and effective way of reducing one of benzene’s double bonds by using an alkali metal (sodium, lithium, or… Continue reading